Neuro-2a is a cell line that was taken from the brain tissue of a strain A albino mouse with neuroblastoma. The Neuro-2a cell line has a modal chromosome number of 95 and produces acetylcholinesterase and tubulin. Neuro-2a cells are susceptible to herpes simplex virus, vesicular stomatitis virus, and human poliovirus 1. Neuro-2a cells are neuroblasts that exhibit a neuronal and amoeboid stem cell mophology and adhere in culture in vitro, which makes them unique and reliable transfection hosts. A reagent to transfect Neuro-2a cells is available for purchase from Altogen Biosystems. This cell line can be used for the study of brain tumors as well as research in cell and molecular biology.
The Neuro-2a cell line was derived from the brain tissue of an albino mouse with a neuroblastoma. The cell line has been used extensively to study the formation of neuroblastomas and the resulting metastasis into bone tissues in children; the cell line is susceptible to viral infection and is consequentially an important model for investigating tumorigenesis in children after birth. With viruses such as poliovirus 1, vesicular stomatitis, and herpes simplex having the capability to be passed on to children during pregnancy, research with non-intrusive transfection reagents accompanying gene therapies can help elucidate cures to virus-caused cancers in children.
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